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During the past several years, much has been written about a preparation called platelet-rich plasma (PRP) and its potential effectiveness in the treatment of injuries.

Many professional athletes have received PRP for various problems, such as sprained knees, acute and chronic tendon injuries as well as arthritis. These types of conditions have typically been treated with medications, physical therapy, or even surgery. Some athletes have credited PRP with their being able to return more quickly to competition.

Even though PRP has received extensive publicity, there are still lingering questions about it, such as:

  • What exactly is platelet-rich plasma?
  • How does it work?
  • What conditions are being treated with PRP?
  • Is PRP treatment effective?

What Is Platelet-rich Plasma (PRP)?

Although blood is mainly a liquid (called plasma), it also contains small solid components (red cells, white cells, and platelets). The platelets are best known for their importance in clotting blood. However, platelets also contain hundreds of proteins called growth factors that are very important in the healing of injuries and have anti-inflammatory effects.

PRP is plasma with many more platelets than what is typically found in blood. The concentration of platelets — and, thereby, the concentration of growth factors — can be 5 to 10 times greater (or richer) than usual.

To create a PRP preparation, blood must first be drawn from a patient. The platelets are separated from other blood cells and their concentration is increased during a process called centrifugation. The platelets are concentrated to enhance their effect (platelet rich). These platelets are then injected into the injured site.

How Does PRP Work?

Although it is not exactly clear how PRP works, laboratory studies have shown that the increased concentration of growth factors in PRP can potentially speed up the healing process. By modifying the PRP preparation, inflammation can be induced at soft tissue sites that need help healing or an anti-inflammatory preparation can be produced for injection into arthritic joints to improve pain.

To speed healing, the injury site is treated with the PRP preparation. This can be done in one of two ways:

PRP can be carefully injected into the injured area. Some areas include acute or chronic tendon problems such as the achilles tendon, patellar tendon, elbow for tennis elbow and golfers elbow as well as into the shoulder for rotator cuff problems.

PRP may also be used to improve healing after surgery for some injuries. This is done with some types of tendon tears to improve healing potential following surgery.

What Conditions are Treated with PRP? Is It Effective?

Research studies are currently being conducted to evaluate the effectiveness of PRP treatment. Recent research has shown that certain tendon problems can have improved outcomes with PRP injections. Additionally, more and more literature is showing the significant effectiveness of PRP in the treatment of mild to moderate knee osteoarthritis. Factors that can influence the effectiveness of PRP treatment include:

  • The area of the body being treated
  • The overall health of the patient
  • Whether the injury is acute (such as from a fall) or chronic (an injury developing over time)
  • The preparation of the PRP, including the cellular makeup of the material that is injected

Chronic Tendon Injuries

According to the research studies currently reported, PRP is effective in the treatment of chronic tendon injuries, especially tennis elbow, a very common injury of the tendons on the outside of the elbow.

The use of PRP for other chronic tendon injuries — such as chronic Achilles tendinitis or inflammation of the patellar tendon at the knee (jumper’s knee) is promising. However, it is difficult to say at this time that PRP therapy is any more effective than traditional treatment of these problems.

Acute Ligament and Muscle Injuries

Much of the publicity PRP therapy has received has been about the treatment of acute sports injuries, such as ligament and muscle injuries. PRP has been used to treat professional athletes with common sports injuries like pulled hamstring muscles in the thigh and knee sprains. 


More recently, PRP has been used during certain types of surgery to help tissues heal. It was first thought to be beneficial in shoulder surgery to repair torn rotator cuff tendons. However, the results so far show little or no benefit when PRP is used in these types of surgical procedures. Recent research has been dedicated to the benefit of PRP in meniscus healing after meniscus repair; however, these studies are only in their infancy.

Surgery to repair torn knee ligaments, especially the anterior cruciate ligament (ACL) is another area where PRP has been applied. At this time, there appears to be little or no benefit from using PRP in this instance.


More and more literature is showing the effectiveness of low-leukocyte PRP in treating low- to moderate-grade osteoarthritis. Some studies have shown that these results can last up to two years. Joints that may benefit from PRP injection include the shoulder, hip, knee and ankle.


PRP has been used in a very limited way to speed the healing of broken bones. So far, it has shown no significant benefit.


Treatment with PRP could hold promise and more and more research studies are demonstrating benefit. Although PRP does appear to be effective in the treatment of certain chronic tendon injuries and low- to moderate-grade knee osteoarthritis, the medical community needs more scientific evidence before it can determine whether PRP therapy is truly effective in other conditions. Ongoing studies show promise with early evidence that PRP can be effective in healing various conditions or managing conditions such as arthritis to avoid or put off surgery.

Even though the success of PRP therapy is still questionable, the risks associated with it are minimal: There may be increased pain at the injection site, but the incidence of other problems — infection, tissue damage, nerve injuries — appears to be no different from that associated with cortisone injections.

If you are considering treatment with PRP, be sure to check your eligibility with your health insurance carrier. Few insurance plans, including workers’ compensation plans, provide even partial reimbursement.